反应详情

Prepared from methyl(2S)-2-{5-[4-(but-3-en-1-yl)-4-methylpiperidin-1-yl]-2-({[2-(but-3-en-1-yloxy)-5-fluorophenyl]methyl}carbamoyl)-7-methylimidazo[1,2-a]pyridin-6-yl}-2-(tert-butoxy)acetate in 12% yield using the same procedure as (2S)-2-(tert-butoxy)-2-{4,25-dimethyl-10-oxo-19-oxa-1,7,11,30-tetraazapentacyclo[23.2.2.16,9.02,7.013,18]triaconta-2,4,6(30),8,13(18),14,16-heptaen-3-yl}acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.90-8.81 (m, 1H), 8.21 (s, 1H), 7.27 (dd, J=8.9, 3.1 Hz, 1H), 7.22 (s, 1H), 7.10-7.03 (m, 1H), 6.95 (dd, J=9.0, 4.4 Hz, 1H), 5.91 (s, 1H), 4.30 (t, J=5.0 Hz, 2H), 4.05-3.95 (m, 2H), 3.79-3.71 (m, 2H), 3.01 (d, J=11.0 Hz, 1H), 2.62 (d, J=11.0 Hz, 1H), 2.37 (s, 3H), 1.82-1.33 (m, 14H), 1.17 (s, 9H), 0.96 (s, 3H); LCMS (ESI, M+1): 609.3.