Hydrochloric Acid → HCID 118308925, compound

Participants

Reaction Steps

tert-Butyl 2-(2-(2-(but-3-en-1-yloxy)phenyl)acetyl)hydrazinecarboxylate (0.28 g, 0.874 mmol, 1 equiv) was treated with 4 N HCl in dioxane (9 mL). After stirring 18 h, the reaction was concentrated in vacuo. The crude product was triturated with ether to provide the product (0.16 g, 71%) as a yellow solid. 1H NMR (400 MHz, CD3OD) δ 7.28 (td, J=7.9, 1.8 Hz, 1H), 7.22 (dd, J=7.5, 1.3 Hz, 1H), 6.98 (d, J=8.3 Hz, 1H), 6.93 (t, J=7.5 Hz, 1H), 5.95 (ddt, J=17.2, 10.3, 6.8 Hz, 1H), 5.18 (dd, J=17.2, 1.6 Hz, 1H), 5.11 (d, J=10.3 Hz, 1H), 4.06 (t, J=6.7 Hz, 2H), 3.63 (s, 2H), 2.56 (q, J=6.6 Hz, 2H); LCMS (ESI, M+1): 221.15.

Provenance & Evidence