(2S)-2-(tert-Butoxy)-2-[(22S)-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid → (2S)-2-(tert-Butoxy)-2-[(22S)-17-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid

Participants

Reaction Steps

Prepared in 37% from methyl(2S)-2-(tert-butoxy)-2-[(22S)-17-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetate following the same procedure as (2S)-2-(tert-butoxy)-2-[(22S)-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.14 (s, 1H), 8.10 (d, J=7.7 Hz, 1H), 7.99 (s, 1H), 7.53 (t, J=7.7 Hz, 1H), 7.35 (d, J=7.7 Hz, 1H), 7.30 (s, 1H), 7.24-7.19 (m, 1H), 7.17 (d, J=5.9 Hz, 2H), 5.90 (br. s., 1H), 4.61 (br. s., 1H), 3.83 (br. s., 1H), 3.64 (br. s., 1H), 3.52-3.29 (m, 2H), 3.17-3.08 (m, 1H), 2.68-2.60 (m, 1H), 2.40 (s, 3H), 1.93-1.46 (m, 10H), 1.19 (s, 3H), 1.17 (s, 9H), 1.07 (d, J=6.2 Hz, 3H); LCMS (ESI, M+1): 644.5.

Provenance & Evidence