Methyl(2S)-2-(tert-butoxy)-2-[(22S)-17,18-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetate → (2S)-2-(tert-Butoxy)-2-[(22S)-17,18-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetic acid

Participants

Reaction Steps

Prepared in 59% yield from Methyl(2S)-2-(tert-butoxy)-2-[(22S)-17,18-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-18-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.10 (d, J=7.3 Hz, 1H), 8.02 (s, 1H), 7.99 (s, 1H), 7.53 (t, J=7.7 Hz, 1H), 7.46-7.37 (m, 2H), 7.31 (d, J=7.7 Hz, 1H), 7.25 (s, 1H), 6.15-6.07 (m, 1H), 5.85-5.75 (m, 2H), 4.64 (br. s., 1H), 4.08-3.88 (m, 3H), 3.59 (t, J=11.4 Hz, 1H), 3.28 (br. s., 1H), 2.68-2.53 (m, 2H), 2.40 (s, 3H), 2.30-2.20 (m, 1H), 1.97-1.85 (m, 2H), 1.79-1.62 (m, 2H), 1.25 (s, 3H), 1.17 (s, 9H), 1.04 (d, J=5.9 Hz, 3H); LCMS (ESI, M): 659.3.

Provenance & Evidence