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HRID1482025

反应详情

EQUATION

反应方程式

HRID 1482025 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc2c(c1)-c1cccc(c1)-c1cn3c(c([C@H](OC(C)(C)C)C(=O)O)c(C)cc3n1)N1CCC(C)(CC1)OCCCC[C@H](C)O2
HCID118316274

未命名化合物

结构：COC(=O)[C@@H](OC(C)(C)C)c1c(C)cc2nc3cn2c1N1CCC(C)(CC1)OCCCC[C@H](C)Oc1cc(F)cc(F)c1-c1cccc-3c1
HCID118319914

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc2nc3cn2c(c1[C@H](OC(C)(C)C)C(=O)O)N1CCC(C)(CC1)OCCCC[C@H](C)Oc1cc(F)cc(F)c1-c1cccc-3c1
HCID118319907

未命名化合物

收率 49%

PROCEDURE

实验过程

Prepared in 49% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,18-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the same procedure as (2S)-2-(tert-butoxy)-2-[(22S)-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.06 (d, J=7.7 Hz, 1H), 7.97 (s, 1H), 7.85 (s, 1H), 7.50 (t, J=7.7 Hz, 1H), 7.25 (s, 2H), 7.01 (d, J=11.4 Hz, 1H), 6.89 (t, J=9.5 Hz, 1H), 5.81 (br. s., 1H), 4.69 (t, J=5.3 Hz, 1H), 3.93-3.82 (m, 1H), 3.59 (t, J=11.2 Hz, 1H), 3.49-3.40 (m, 1H), 3.26 (d, J=7.0 Hz, 1H), 2.63 (d, J=9.9 Hz, 1H), 2.40 (s, 3H), 1.89-1.57 (m, 10H), 1.50 (d, J=7.7 Hz, 1H), 1.19 (s, 3H), 1.16 (s, 9H), 1.11 (d, J=5.9 Hz, 3H); LCMS (ESI, M): 661.3.