(2S)-2-(tert-Butoxy)-2-[(22S)-18-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetic acid → (2S)-2-[(2-methylpropan-2-yl)oxy]-2-[(22S)-4,17,18,22,28-pentamethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10,12,14(33),15(20),16,18,24-undecaen-3-yl]acetic acid

Participants

Reaction Steps

Prepared in 69% from methyl(2S)-2-(tert-butoxy)-2-[(22S)-4,17,18,22,28-pentamethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetate following the procedure of (2S)-2-(tert-butoxy)-2-[(22S)-18-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.06-7.97 (m, 3H), 7.50 (t, J=7.7 Hz, 1H), 7.31-7.26 (m, 2H), 7.10 (s, 1H), 7.00 (s, 1H), 6.10 (dd, J=14.3, 7.3 Hz, 1H), 5.92 (br. s., 1H), 5.77 (d, J=15.4 Hz, 1H), 4.57 (s, 1H), 4.03-3.89 (m, 3H), 3.64 (t, J=10.8 Hz, 1H), 3.10 (d, J=7.7 Hz, 1H), 2.63 (d, J=8.1 Hz, 1H), 2.56-2.53 (m, 1H), 2.40 (s, 3H), 2.27 (s, 3H), 2.23 (d, J=7.7 Hz, 1H), 2.20 (s, 3H), 1.98-1.91 (m, 1H), 1.87 (d, J=13.2 Hz, 1H), 1.77-1.67 (m, 2H), 1.25 (s, 3H), 1.18 (s, 9H), 1.01 (d, J=5.9 Hz, 3H); LCMS (ESI, M):651.4.

Provenance & Evidence