HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4-fluoro-5-methylphenol → (S)-1-Bromo-5-fluoro-4-methyl-2-(pent-4-en-2-yloxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4-fluoro-5-methylphenol | HCID 84672831 | — |
| Reactant | (S)-1-Bromo-4-fluoro-2-(pent-4-en-2-yloxy)benzene | HCID 118308842 | — |
| Product | (S)-1-Bromo-5-fluoro-4-methyl-2-(pent-4-en-2-yloxy)benzene | HCID 89971081 | 59% |
Reaction Steps
Prepared in 59% yield from 2-bromo-4-fluoro-5-methylphenol following the same procedure as (S)-1-bromo-4-fluoro-2-(pent-4-en-2-yloxy)benzene. 1H NMR (400 MHz, CDCl3) δ 7.21 (d, J=8.8 Hz, 1H), 6.75 (d, J=6.8 Hz, 1H), 5.91 (ddt, J=17.2, 10.2, 7.2 Hz, 1H), 5.20-5.07 (m, 2H), 4.42-4.26 (m, 1H), 2.60-2.48 (m, 1H), 2.45-2.37 (m, 1H), 2.23 (d, J=1.8 Hz, 3H), 1.33 (d, J=6.3 Hz, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409922B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-3f54c87fae0f44c5b5abfa80a5c23f7a |
| Source note | uspto-grants-2016_08 |