HRID1482041

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OC)c(C)cc3nc(-c4cccc(Br)c4)cn23)CC1

HCID118308811

未命名化合物

结构：C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OC)c(C)cc3nc(-c4cccc(-c5cc(C)ccc5O)c4)cn23)CC1

HCID118308900

未命名化合物

HCID131736664

未命名化合物

PRODUCTS

生成物

结构：C=CCOC1(C)CCN(c2c([C@H](OC(C)(C)C)C(=O)OC)c(C)cc3nc(-c4cccc(-c5c(O)cc(C)cc5F)c4)cn23)CC1

HCID118308851

未命名化合物

收率 100%

PROCEDURE

实验过程

Prepared in 100% yield from (2-fluoro-6-hydroxy-4-methylphenyl)boronic acid and (S)-methyl 2-(5-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(3-bromophenyl)-7-methylimidazo[1,2-a]pyridin-6-yl)-2-(tert-butoxy)acetate following the procedure of (S)-methyl 2-(5-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2′-hydroxy-5′-methyl-[1,1′-biphenyl]-3-yl)-7-methylimidazo[1,2-a]pyridin-6-yl)-2-(tert-butoxy)acetate. LCMS (ESI, M+1): 630.3.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-50b64751f2ba4fe1a8f449aa9f9950e5
来源数据集: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09409922B2
来源说明: uspto-grants-2016_08

反应 SMILES

[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([OH:9])[C:3]=1B(O)O.[CH2:13]([O:16][C:17]1([CH3:50])[CH2:22][CH2:21][N:20]([C:23]2[N:28]3[CH:29]=[C:30]([C:32]4[CH:37]=[CH:36][CH:35]=[C:34](Br)[CH:33]=4)[N:31]=[C:27]3[CH:26]=[C:25]([CH3:39])[C:24]=2[C@H:40]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])[C:41]([O:43][CH3:44])=[O:42])[CH2:19][CH2:18]1)[CH:14]=[CH2:15].C(OC1(C)CCN(C2N3C=C(C4C=C(C5C=C(C)C=CC=5O)C=CC=4)N=C3C=C(C)C=2[C@H](OC(C)(C)C)C(OC)=O)CC1)C=C>>[CH2:13]([O:16][C:17]1([CH3:50])[CH2:18][CH2:19][N:20]([C:23]2[N:28]3[CH:29]=[C:30]([C:32]4[CH:33]=[C:34]([C:3]5[C:4]([OH:9])=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=5[F:1])[CH:35]=[CH:36][CH:37]=4)[N:31]=[C:27]3[CH:26]=[C:25]([CH3:39])[C:24]=2[C@H:40]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])[C:41]([O:43][CH3:44])=[O:42])[CH2:21][CH2:22]1)[CH:14]=[CH2:15]