Methyl(2S)-2-(tert-butoxy)-2-[(22S)-16-fluoro-4,18,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate → (2S)-2-(tert-Butoxy)-2-[(22S)-16-fluoro-4,18,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid

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Reaction Steps

Prepared in 41% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-16-fluoro-4,18,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-18-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.04 (d, J=7.7 Hz, 1H), 7.98 (s, 1H), 7.85 (s, 1H), 7.49 (t, J=7.5 Hz, 1H), 7.30 (s, 1H), 7.24 (d, J=7.3 Hz, 1H), 6.86 (s, 1H), 6.71 (d, J=10.6 Hz, 1H), 5.90 (br. s., 1H), 4.66 (br. s., 1H), 3.87 (br. s., 1H), 3.63 (br. s., 1H), 3.49-3.42 (m, 2H), 3.12 (br. s., 1H), 2.64 (d, J=10.6 Hz, 1H), 2.40 (s, 3H), 2.37 (s, 3H), 1.93-1.51 (m, 10H), 1.20 (s, 3H), 1.18 (s, 9H), 1.10 (d, J=5.9 Hz, 3H) LCMS (ESI, M): 657.4.

Provenance & Evidence