tert-Butyl 2-(3-bromophenyl)-5-chloro-7,8-dimethylimidazo[1,2-a]pyridine-6-carboxylate → 2-(3-Bromophenyl)-5-chloro-7,8-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid

Participants

Reaction Steps

A solution of tert-butyl 2-(3-bromophenyl)-5-chloro-7,8-dimethylimidazo[1,2-a]pyridine-6-carboxylate (1 g, 2.30 mmol, 1 equiv) in TFA (5 mL) was stirred 3 h. The reaction mixture was then concentrated in vacuo and the residue was triturated with ether. The solid was filtered and washed with ether to provide the product (0.70 g, 80%). LCMS (ESI, M+1): 379.0.

Provenance & Evidence