2-(3-Bromophenyl)-5-chloro-7,8-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid → Methyl 2-(2-(3-bromophenyl)-5-chloro-7,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-oxoacetate

HRID 1482064Notes

Reaction equation

HRID 1482064 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]3[C:15]([CH3:16])=[C:14]([CH3:17])[C:13]([C:18](O)=[O:19])=[C:12]([Cl:21])[N:11]3[CH:22]=2)[CH:5]=[CH:6][CH:7]=1.BrC1C=C(C2N=C3C=C(C)C(C(=O)[C:40]([O:42][CH3:43])=[O:41])=C(Cl)N3C=2)C=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]3[C:15]([CH3:16])=[C:14]([CH3:17])[C:13]([C:18](=[O:19])[C:40]([O:42][CH3:43])=[O:41])=[C:12]([Cl:21])[N:11]3[CH:22]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1183087932-(3-Bromophenyl)-5-chloro-7,8-dimethylimidazo[1,2-a]pyridine-6-carboxylic acidHCID 118308817Methyl 2-(2-(3-bromophenyl)-5-chloro-7-methylimidazo[1,2-a]pyridin-6-yl)-2-oxoacetate

Product 1

HCID 118308831Methyl 2-(2-(3-bromophenyl)-5-chloro-7,8-dimethylimidazo[1,2-a]pyridin-6-yl)-2-oxoacetate

Procedure

Prepared from 2-(3-bromophenyl)-5-chloro-7,8-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid following the same procedure as methyl 2-(2-(3-bromophenyl)-5-chloro-7-methylimidazo[1,2-a]pyridin-6-yl)-2-oxoacetate. LCMS (ESI, M+1): 420.85.

Sources & evidence

ORD record
ord-2821c13c64e4419cb92b9f18024f1136
Source dataset
uspto-grants-2016_08
Patent number
US09409922B2

Reaction notes

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