Methyl(2S)-2-(tert-butoxy)-2-[(22S)-19-fluoro-4,5,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate → (2S)-2-(tert-Butoxy)-2-[(22S)-19-fluoro-4,5,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid

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Reaction Steps

Prepared in 7.14% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-19-fluoro-4,5,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.08 (s, 1H), 8.02 (d, J=7.7 Hz, 1H), 7.94 (s, 1H), 7.60-7.54 (m, 1H), 7.43 (d, J=7.3 Hz, 1H), 7.33-7.26 (m, 2H), 7.22-7.15 (m, 1H), 5.87 (br. s., 1H), 4.32 (br. s., 1H), 4.01-3.92 (m, 1H), 3.58-3.38 (m, 4H), 2.70 (d, J=9.9 Hz, 1H), 2.47 (s, 3H), 2.31 (s, 3H), 1.94-1.54 (m, 10H), 1.20 (s, 3H), 1.15 (s, 9H), 0.78 (d, J=5.9 Hz, 3H); LCMS (ESI, M): 657.4.

Provenance & Evidence