Methyl(2S)-2-(tert-butoxy)-2-[(22S)-17-fluoro-5-(4-fluorophenyl)-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate → (2S)-2-(tert-Butoxy)-2-[(22S)-17-fluoro-5-(4-fluorophenyl)-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid

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Reaction Steps

Prepared in 5.1% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-17-fluoro-5-(4-fluorophenyl)-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.12 (s, 1H), 8.05 (s, 1H), 7.88 (d, J=7.7 Hz, 1H), 7.48-7.41 (m, 3H), 7.36-7.29 (m, 3H), 7.22-7.12 (m, 3H), 5.98 (br. s., 1H), 4.61 (br. s., 1H), 3.93-3.81 (m, 1H), 3.66 (t, J=11.0 Hz, 1H), 3.38 (br. s., 4H), 2.18 (s, 3H), 1.95-1.63 (m, 9H), 1.55 (br. s., 1H), 1.22 (s, 3H), 1.19 (s, 9H), 1.07 (d, J=5.9 Hz, 3H). LCMS (ESI, M): 737.4.

Provenance & Evidence