HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-3,5-difluorophenol → (S)-2-Bromo-1,5-difluoro-3-(pent-4-en-2-yloxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-3,5-difluorophenol | HCID 22144860 | — |
| Reactant | (S)-2-(4,5-difluoro-2-(pent-4-en-2-yloxy)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione | HCID 131736668 | — |
| Product | (S)-2-Bromo-1,5-difluoro-3-(pent-4-en-2-yloxy)benzene | HCID 118308799 | 80% |
Reaction Steps
Prepared from 2-bromo-3,5-difluorophenol in 80% yield following the procedure for (S)-2-(4,5-difluoro-2-(pent-4-en-2-yloxy)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione. 1H NMR (400 MHz, CDCl3) δ 6.59-6.43 (m, 2H), 5.94-5.80 (m, 1H), 5.22-5.09 (m, 2H), 4.47-4.36 (m, 1H), 2.59-2.37 (m, 2H), 1.37 (d, J=6.3 Hz, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409922B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-32f2c6a027cf4c95b0fc734ce1f2fdc8 |
| Source note | uspto-grants-2016_08 |