Methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,18-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate → (2S)-2-(tert-Butoxy)-2-[(22S)-16,18-difluoro-4,5,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid

Participants

Reaction Steps

Prepared in 57.5% yield from Methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,18-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.12 (d, J=8.1 Hz, 1H), 7.99 (s, 1H), 7.83 (s, 1H), 7.52 (t, J=7.7 Hz, 1H), 7.25 (d, J=7.7 Hz, 1H), 7.01 (d, J=11.4 Hz, 1H), 6.88 (t, J=8.8 Hz, 1H), 6.05 (br. s., 1H), 4.69 (br. s., 1H), 3.92-3.81 (m, 1H), 3.63 (t, J=10.6 Hz, 1H), 3.51-3.38 (m, 2H), 3.05 (d, J=8.4 Hz, 1H), 2.63 (d, J=7.7 Hz, 1H), 2.51 (br. s., 3H), 2.31 (s, 3H), 1.93-1.81 (m, 2H), 1.80-1.58 (m, 7H), 1.50 (br. s., 1H), 1.20 (s, 3H), 1.17 (s, 9H), 1.11 (d, J=5.9 Hz, 3H); LCMS (ESI, M): 675.3.

Provenance & Evidence