Methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,18-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate → (2S)-2-(tert-Butoxy)-2-[(22S)-16,18-difluoro-4,5,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid

Participants

Reaction Steps

Prepared in 7.2% yield from Methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,18-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.09 (d, J=7.7 Hz, 1H), 7.93 (s, 1H), 7.74 (s, 1H), 7.53 (t, J=7.7 Hz, 1H), 7.25 (d, J=7.3 Hz, 1H), 7.01 (d, J=12.1 Hz, 1H), 6.92-6.84 (m, 1H), 6.08 (br. s., 1H), 4.69 (br. s., 1H), 3.87-3.78 (m, 1H), 3.70 (t, J=10.3 Hz, 1H), 3.50-3.40 (m, 2H), 2.89 (br. s., 1H), 2.69 (d, J=9.5 Hz, 1H), 2.49 (s, 3H), 2.33 (s, 3H), 1.93-1.46 (m, 10H), 1.20 (s, 12H), 1.13 (d, J=5.9 Hz, 3H); LCMS (ESI, M): 675.3.

Provenance & Evidence