HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4,6-difluorophenol → (S)-1-bromo-3,5-difluoro-2-(pent-4-en-2-yloxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4,6-difluorophenol | HCID 2736290 | — |
| Reactant | (S)-1-Bromo-4,5-difluoro-2-(pent-4-en-2-yloxy)benzene | HCID 118308806 | — |
| Product | (S)-1-bromo-3,5-difluoro-2-(pent-4-en-2-yloxy)benzene | HCID 118308830 | 92% |
Reaction Steps
Prepared in 92% yield from 2-bromo-4,6-difluorophenol following the procedure for (S)-1-bromo-4,5-difluoro-2-(pent-4-en-2-yloxy)benzene. 1H NMR (400 MHz, CDCl3) δ 7.19-7.06 (m, 1H), 6.85 (ddd, J=10.9, 8.2, 3.0 Hz, 1H), 5.90 (ddt, J=17.2, 10.1, 7.0 Hz, 1H), 5.19-5.07 (m, 2H), 4.46-4.30 (m, 1H), 2.65-2.48 (m, 1H), 2.48-2.39 (m, 1H), 1.31 (dd, J=6.1, 0.6 Hz, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409922B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-5e6631952be94fd3b44bf09265fcbef3 |
| Source note | uspto-grants-2016_08 |