HRID1482104

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75927

Phenol, 3,4-difluoro-

C6H4F2O

结构：C=CC[C@H](C)Oc1cc(F)c(F)cc1B1OC(=O)CN(C)CC(=O)O1

HCID131736668

未命名化合物

PRODUCTS

生成物

HCID118308803

1,2-Difluoro-4-[[(1S)-1-methyl-3-buten-1-yl]oxy]benzene

C11H12F2O

PROCEDURE

实验过程

Prepared in 69% from 3,4-difluorophenol following the procedure for (S)-2-(4,5-difluoro-2-(pent-4-en-2-yloxy)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione. 1H NMR (400 MHz, CDCl3) δ 7.11-6.97 (m, 1H), 6.72 (ddd, J=12.1, 6.6, 2.9 Hz, 1H), 6.64-6.54 (m, 1H), 5.85 (ddt, J=17.2, 10.2, 7.0 Hz, 1H), 5.19-5.09 (m, 2H), 4.38-4.23 (m, 1H), 2.48 (qd, J=7.0, 5.9 Hz, 1H), 2.40-2.28 (m, 1H), 1.31 (d, J=6.0 Hz, 3H); 19F NMR (376 MHz, CDCl3) δ −135.75 (d, J=20.8 Hz, 1F), −148.32 (d, J=22.5 Hz, 1F).