Methyl(2S)-2-(tert-butoxy)-2-[(22S)-18-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate → Methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,17-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate

Participants

Reaction Steps

Prepared in 69.8% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S,24Z)-16,17-difluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18,24-undecaen-3-yl]acetate following the procedure for methyl(2S)-2-(tert-butoxy)-2-[(22S)-18-fluoro-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate. 1H NMR (500 MHz, CDCl3) δ 8.21 (dt, J=7.9, 1.3 Hz, 1H), 8.01 (s, 1H), 7.90 (t, J=1.5 Hz, 1H), 7.56 (t, J=7.7 Hz, 1H), 7.38-7.33 (m, 2H), 7.14-7.06 (m, 1H), 6.72-6.68 (m, 1H), 6.07 (br. s., 1H), 4.51-4.45 (m, 1H), 4.04-3.95 (m, 1H), 3.77 (t, J=10.8 Hz, 1H), 3.71 (s, 3H), 3.56-3.50 (m, 1H), 3.50-3.45 (m, 1H), 3.09 (d, J=10.1 Hz, 1H), 2.71 (d, J=7.7 Hz, 1H), 2.48 (d, J=0.9 Hz, 3H), 2.00-1.92 (m, 2H), 1.85-1.71 (m, 8H), 1.30 (s, 3H), 1.27 (s, 9H), 1.13 (d, J=6.1 Hz, 3H); LCMS (ESI, M+1): 676.80.

Provenance & Evidence