Methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,17-difluoro-5-(1-hydroxyethyl)-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate → (2S)-2-(tert-Butoxy)-2-[(22S)-16,17-difluoro-5-(1-hydroxyethyl)-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid

Participants

Reaction Steps

Prepared in 19.0% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-16,17-difluoro-5-(1-hydroxyethyl)-4,22,28-trimethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, DMSO-d6) δ 8.08 (d, J=7.7 Hz, 1H), 7.97 (s, 1H), 7.90 (s, 1H), 7.57 (t, J=7.7 Hz, 1H), 7.40 (q, J=9.8 Hz, 1H), 7.35 (d, J=7.3 Hz, 1H), 7.00 (d, J=7.3 Hz, 1H), 5.96 (br. s., 1H), 5.41 (br. s., 1H), 4.62 (br. s., 1H), 3.89-3.81 (m, 1H), 3.64-3.55 (m, 1H), 3.42-3.36 (m, 2H), 3.17 (br. s., 1H), 2.64 (d, J=7.3 Hz, 1H), 2.37 (s, 3H), 1.94-1.58 (m, 10H), 1.52 (d, J=6.6 Hz, 3H), 1.19 (s, 3H), 1.16 (s, 9H), 1.08 (d, J=5.9 Hz, 3H); LCMS (ESI, M+1): 706.05.

Provenance & Evidence