Methyl(2S)-2-(tert-butoxy)-2-[(22S)-17-fluoro-4,22,28-trimethyl-5-(propan-2-yl)-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate → (2S)-2-(tert-Butoxy)-2-[(22S)-17-fluoro-4,22,28-trimethyl-5-(propan-2-yl)-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid

Participants

Reaction Steps

Prepared in 98% yield from methyl(2S)-2-(tert-butoxy)-2-[(22S)-17-fluoro-4,22,28-trimethyl-5-(propan-2-yl)-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetate following the procedure for (2S)-2-(tert-butoxy)-2-[(22S)-8-chloro-4,17,22,28-tetramethyl-21,27-dioxa-1,7,34-triazahexacyclo[26.2.2.16,9.110,14.02,7.015,20]tetratriaconta-2,4,6(34),8,10(33),11,13,15(20),16,18-decaen-3-yl]acetic acid. 1H NMR (500 MHz, METHANOL-d4) δ 8.15-8.10 (m, 2H), 8.00 (s, 1H), 7.51 (t, J=7.6 Hz, 1H), 7.28 (d, J=7.7 Hz, 1H), 7.13-7.07 (m, 2H), 7.06-7.00 (m, 1H), 6.01 (s, 1H), 4.55 (td, J=6.1, 3.6 Hz, 1H), 4.02 (t, J=11.2 Hz, 1H), 3.89-3.78 (m, 1H), 3.76-3.68 (m, 1H), 3.61-3.52 (m, 3H), 2.76 (d, J=10.2 Hz, 1H), 2.49 (s, 3H), 2.01-1.87 (m, 6H), 1.86-1.72 (m, 5H), 1.64 (d, J=5.2 Hz, 1H), 1.55 (dd, J=7.1, 0.9 Hz, 6H), 1.26 (s, 3H), 1.21 (s, 9H), 1.09 (d, J=6.0 Hz, 3H); LCMS (ESI, M+1): 686.4.

Provenance & Evidence