HCID 86720844, compound → HCID 86720845, compound

Participants

Reaction Steps

The methyl-2-(tetracen-5-yl)benzoate (2.58 g, 7.13 mmol) was dissolved in 200 mL of THF. A 3M methyl magnesium bromide-diethyl ether solution (7.84 mL, 23.5 mmol) was added dropwise in a nitrogen atmosphere under reflux at the boiling point and the mixture was reacted for 2 hours to obtain 2-(2-(tetracen-5-yl)phenyl)propan-2-ol at a yield of 81%. The 2-(2-(tetracen-5-yl)phenyl)propan-2-ol (2.09 g, 5.78 mmol) was added to a solvent mixture containing 100 mL of acetic acid and 20 mL of 37% hydrochloric acid and the mixture was reacted for 5 hours under reflux at the boiling point to synthesize Illustrative Compound A-8 at a yield of 36%.

Provenance & Evidence