HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(tert-Butyldithio)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl (2-(tert-butyldisulfanyl)ethyl)carbamate | HCID 89668308 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(tert-Butyldithio)ethanamine | HCID 434077 | 335.3% |
Reaction Steps
A solution of TFA (1.0 ml) in DCM (1.0 ml) was added to tert-butyl (2-(tert-butyldisulfanyl)ethyl)carbamate (Compound 6b-A, 100 mg, 0.377 mmol), and the mixture was stirred at room temperature for 15 minutes. The reaction solution was concentrated under reduced pressure to afford the title compound (209 mg, quant.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409952B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-2e433adbd07e4a2e9758f949840e5181 |
| Source note | uspto-grants-2016_08 |