Ammonia → HCID 131736704, compound

HRID 1482313Notes

Reaction equation

[CH2:1]([CH2:5][C@H:6]([NH2:10])[C:7]([OH:9])=[O:8])[CH2:2][CH2:3][NH2:4].[ClH:11].[NH3:12]>>[ClH:11].[NH4+:4].[NH4+:12].[NH2:10][C@@H:6]([CH2:5][CH2:1][CH2:2][CH2:3][NH2:4])[C:7]([O-:9])=[O:8].[NH2:10][C@@H:6]([CH2:5][CH2:1][CH2:2][CH2:3][NH2:4])[C:7]([O-:9])=[O:8]

Participants

Reactant 2

HCID 222Ammonia

HCID 69568L-Lysine monohydrochloride

Product 1

HCID 131736704HCID 131736704, compound

Procedure

L(+)-lysine monohydrochloride (3.08 g, 16.86 mmol) was cooled in an ice bath, followed by addition of aqueous ammonia (15 mL). The reaction solution was stirred at the same temperature for 25 minutes and then concentrated under reduced pressure, and the resulting crude product (3.20 g) was directly used for the next step.

Workup

concentrationconcentrated under reduced pressure

Sources & evidence

ORD record: ord-c833bad9db90490f957818cfb640e811
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09409952B2

Reaction notes

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