Methyl 2-acetamidoacrylate → HCID 118023697, compound

HRID 1482397Notes

Reaction equation

HRID 1482397 reaction equation
ClC1C=CN(C2C=NC=CC=2)N=1.Cl.Cl.[NH:15]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)[NH2:16].[C:23]([NH:26][C:27](=[CH2:32])[C:28](OC)=[O:29])(=[O:25])[CH3:24]>>[O:29]=[C:28]1[CH:27]([NH:26][C:23](=[O:25])[CH3:24])[CH2:32][N:15]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[NH:16]1

Participants

4

Reactant 3

HCID 98644Methyl 2-acetamidoacrylateHCID 171324893-Hydrazinylpyridine dihydrochlorideHCID 674995403-(3-chloro-1H-pyrazol-1-yl)pyridine

Product 1

HCID 118023697HCID 118023697, compound

Procedure

3-(3-Chloro-1H-pyrazol-1-yl)pyridine (5b) in Scheme 1 may alternatively be prepared by reacting 3-hydrazinopyridine dihydrochloride with methyl 2-acetamidoacrylate to yield N-(3-oxo-1-(pyridin-3-yl)pyrazolidin-4-yl)acetamide and subsequent chlorination/elimination as shown in Scheme 2, step a1.

Sources & evidence

ORD record
ord-342c557ab8a34b2abb47591750cd5971
Source dataset
uspto-grants-2016_08
Patent number
US09414594B2

Reaction notes

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