HCID 118022928, compound → 3-(3-chloro-1H-pyrazol-1-yl)pyridine

HRID 1482407Notes

Reaction equation

HRID 1482407 reaction equation
[Cl:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[N:3]=1>C(O)(CC)(C)C.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[CH:6]=[CH:5][N:4]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[N:3]=1

Participants

4

Reactant 1

HCID 118022928HCID 118022928, compound

Product 1

HCID 674995403-(3-chloro-1H-pyrazol-1-yl)pyridine

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 64052-Methyl-2-butanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 3-chloro-4,5-dihydro-1-(3-pyridinyl)-1H-pyrazole (0.182 g, 1.00 mmol) in tert-amyl alcohol (2 mL) was added manganese (IV) oxide (0.870 g, 10 mmol) (Carus black). The mixture was heated at 80° C. for 19 hours. LC analysis indicated complete conversion to product. The reaction was not worked up.

Sources & evidence

ORD record
ord-d81b09ab9af947208976c071550eee8c
Source dataset
uspto-grants-2016_08
Patent number
US09414594B2

Reaction notes

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