HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(4-Chlorophenyl)cyclobutanone oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 2-(4-Chlorophenyl)cyclobutanone | HCID 89823005 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-Chlorophenyl)cyclobutanone oxime | HCID 131736706 | — |
Reaction Steps
A solution of 2-(4-chlorophenyl)cyclobutanone (1.122 g, 6.09 mmol), hydroxylamine hydrochloride (3.541 g. 8.2 eq.) and 36 ml of 5% NaOH in 30 ml EtOH was heated at reflux for 2 h. The solution was cooled, adjusted to pH 6, and extracted with CHCl3. The organic extract was washed with brine and dried. Filtration and concentration yielded 2-(4-chlorophenyl)cyclobutanone oxime as an oil. 1 g (84%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09414589B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-5cb33c3b4ce54ca58200a6b306d41575 |
| Source note | uspto-grants-2016_08 |