HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dichlorobenzoic acid → HCID 73672103, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dichlorobenzoic acid | HCID 5765 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 86716019 | HCID 86716019 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 73672103 | HCID 73672103 | 35.5% |
Reaction Steps
A mixture of 2-(4,4-difluoro-piperidin-1-yl)-2-(6-fluoro-pridin-3-yl)-ethylamine (100 mg, 0.38 mmol), 2,3-dichlorobenzoic acid (51 mg, 0.28 mmol), HOBT (57 mg, 0.42 mmol), EDC.HCl (81 mg, 0.42 mmol) and DIPEA (108 mg, 0.84 mmol) in DMF (4 mL) was stirred at room temperature overnight. The mixture was purified by preparative HPLC directly to yield the title compound (43 mg, yield: 30%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09415055B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-ae82d4bff121489b90385b3001dd72ea |
| Source note | uspto-grants-2016_08 |