1-(2-Methoxyphenyl)piperazine → HCID 76282189, compound

Participants

Reaction Steps

1-(4-chlorobutyl)-1H-benzimidazole (7.51 g, 0.036 mol) was dissolved into 100 ml of acetonitrile, 2-methoxyphenyl piperazine (5.77 g, 0.03 mol), diisopropylethylamine (15.5 g, 0.12 mol) and potassium iodide (5.0 g, 0.03 mol) were respectively added. The mixture was stirred for 10 min at ambient temperature, and then heated and refluxed to react for 10-15 hours. The mixture was cooled down to ambient temperature and filtered. The filtrate was concentrated to produce oily products, and treated by chromatography with neutral Al2O3, eluted with dichloromethane/methanol mixture to produce 7.7 g compound (I-4) with a yield of 70.6%. ESI-MS [M+H]+: m/z 365.2.

Provenance & Evidence