Sodium Hydroxide → 1-(4-chlorobutyl)-6-fluoro-1H-benzotriazole

Participants

Reaction Conditions

Reaction Steps

6-fluoro-1H-benzotriazole (13.7 g, 0.10 mol) is dissolved into 100 ml of 30% wt. sodium hydroxide, 4-chlorobromobutane (34.3 g, 0.20 mol), tetrabutyl ammonium bromide (0.8 g) are added, and mixed for 5 min. The reaction solution is gradually heated to 60° C., stirred for reaction for 2 hours. Post treatment was performed based on common method one for synthesis. The solution was separated and purified by HPLC to produce 8.9 g of 1-(4-chlorobutyl)-6-fluoro-1H-benzotriazole, with a yield of 39.0%.

Provenance & Evidence