Sodium Hydroxide → HCID 118386926, compound

Participants

Reaction Conditions

Reaction Steps

5,6-dimethyl-1H-benzotriazole (14.7 g, 0.10 mol) is dissolved into 100 ml of 30% wt. sodium hydroxide, 4-chlorobromobutane (34.3 g, 0.20 mol), tetrabutyl ammonium bromide (0.8 g) are added, and mixed for 5 min. The reaction solution is gradually heated to 60° C., stirred for reaction for 2 hours. Post treatment was performed based on common method one for synthesis. The solution was separated and purified by HPLC to produce 17.4 g of 1-(4-chlorobutyl)-5,6-dimethyl-1H-benzotriazole, with a yield of 73.2%.

Provenance & Evidence