HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Boc-4-(aminomethyl)piperidine → 4-{[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Boc-4-(aminomethyl)piperidine | HCID 736817 | — |
| Reactant | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | — |
| Product | 4-{[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester | HCID 86603266 | — |
Reaction Steps
Intermediate 1 was coupled with 4-Aminomethyl-piperidine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 417.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732444B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-cfdad71f24f1403c9b44c193f396ce5c |
| Source note | uspto-grants-2010_06 |