1-Bromo-3-chloropropane → HCID 118386856, compound

Participants

Reaction Conditions

Reaction Steps

6-chloro-1H-benzotriazole (15.4 g, 0.10 mol) is dissolved into 100 ml of 30% wt. sodium hydroxide, 3-chlorobromopropane (31.4 g, 0.10 mol), tetrabutyl ammonium bromide (0.8 g) are added, and mixed for 5 min. The reaction solution is gradually heated to 60° C., stirred for reaction for 2 hours. Post treatment was performed based on common method two for synthesis. The solution was separated and purified by HPLC to produce 7.3 g of 1-(3-chloropropyl)-6-chloro-1H-benzotriazole, with a yield of 31.7%.

Provenance & Evidence