Potassium Iodide → HCID 178490257, compound

Participants

Reaction Steps

N-(3-chloropropyl)-6-methoxyl benzotriazole (0.06 mol) was dissolved into 150 ml of acetonitrile, 4-(3-benzisoxazolyl) piperidine (0.05 mol), diisopropylethylamine (0.2 mol) and potassium iodide (0.05 mol) were respectively added. The mixture was stirred for 10 min at ambient temperature, and then heated and refluxed to react for 15 hours. The mixture was cooled down to ambient temperature and filtered. The filtrate was concentrated to produce oily products, and treated by chromatography with neutral Al2O3, purified, eluted with dichloromethane/methanol mixture to produce 13.14 g N-(3-(6-methoxyl benzotriazolyl)propyl)-4-(3-benzisoxazolyl)piperidine (I-93) with a yield of 67.2%. ESI-MS [M+H]+: m/z 391.2.

Provenance & Evidence