反应详情

To a solution of 2-chloro-5-fluoro-N-(3-nitrophenyl)pyrimidin-4-amine (0.400 g) and 4-[(2-methoxyethoxy)methoxy]aniline (0.458 g), in ethanol (20 mL), was added acetic acid (4.65 mg). The reaction mixture was heated to reflux for 24 hr. Completion of reaction was monitored by TLC using hexane:ethyl acetate (8:2) as mobile phase. After completion of the reaction, ethanol was removed under reduced pressure at 40° C. To the residue water (25 mL) was added and mixture was extracted with ethyl acetate. The organic layer was dried over sodium sulfate and distilled under reduced pressure to give 0.4 g of 5-fluoro-N2-(4-((2-methoxyethoxy)methoxy)phenyl)-N4-(3-nitrophenyl)pyrimidine-2,4-diamine as a solid.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 24 hr
3. customCompletion of reaction
4. customwas removed under reduced pressure at 40° C
5. additionTo the residue water (25 mL) was added
6. extractionmixture was extracted with ethyl acetate
7. dry with materialThe organic layer was dried over sodium sulfate
8. distillationdistilled under reduced pressure