2-(4-Nitrophenoxy)ethanol → 2-(4-Aminophenoxy)ethanol

Participants

Reaction Steps

To a suspension of Pd/C (0.27 g) in methanol (27 mL), 2-(4-nitrophenoxy)ethanol (2.70 g) was added under nitrogen atmosphere into the 50 mL 3-neck RBF at room temperature. Hydrogen gas was bubbled for 1-2 hr at room temperature. The reaction was monitored on TLC using chloroform:methanol (9.8:0.2) as mobile phase. After completion, the reaction mixture was filtered using Celite and washed with methanol. The filtrate was concentrated under reduced pressure at 40° C. to give 1.8 g of 2-(4-aminophenoxy)ethanol as a dark brown liquid.

Provenance & Evidence