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In a 25 mL 3-neck RBF equipped with a calcium chloride guard tube, N-(3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)-2,3-dihydroxypropanamide (2.0 g), in THF (25 mL), was added TEA (0.724 g). The reaction mixture was cooled to 0° C. and a solution of CH3SO2Cl (0.491 g) in THF was added dropwise. The reaction mixture was stirred at room temperature for 3 hr. The reaction was monitored on TLC using CHCl3:methanol (9:1) as mobile phase. After completion of reaction, water and saturated NaHCO3 solution were added. The mixture was extracted into ethyl acetate. The organic layer was washed dried over sodium sulfate and concentrated under reduced pressure at 40° C. The crude material was purified by Combiflash eluted with 2.2% methanol in CHCl3 to give 0.24 g of 3-((3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)amino)-2-hydroxy-3-oxopropyl methanesulfonate.

1. customIn a 25 mL 3-neck RBF equipped with a calcium chloride guard tube
2. additionwere added
3. extractionThe mixture was extracted into ethyl acetate
4. washThe organic layer was washed
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated under reduced pressure at 40° C
7. customThe crude material was purified by Combiflash
8. washeluted with 2.2% methanol in CHCl3