N-Methyl-4-anisidine → HCID 66762693, compound

HRID 1482810Notes

Reaction equation

HRID 1482810 reaction equation
Cl[S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([NH:20][CH3:21])=[CH:18][CH:17]=1>>[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([N:20]([CH3:21])[S:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=2)(=[O:4])=[O:3])=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 22250N-Methyl-4-anisidineHCID 823854-(Chlorosulfonyl)benzoic acid

Product 1

HCID 66762693HCID 66762693, compound

Procedure

4-(chlorosulfonyl)benzoic acid (0.5 g, 2.27 mmol) was treated with 4-methoxy-N-methylaniline (933 mg, 6.80 mmol) using method A to give 4-(N-(4-methoxyphenyl)-N-methylsulfamoyl)benzoic acid as a yellow solid. Yield: 617 mg (85%). 1H-NMR: 8.10 (d, J=8.5 Hz, 2H), 7.63 (d, J=8.5 Hz, 2H), 6.98 (d, J=8.5 Hz, 2H), 6.88 (d, J=8.5 Hz, 2H), 3.74 (s, 3H), 3.13 (s, 3H).

Sources & evidence

ORD record
ord-56cfb58fe0a645c4870ce7e0d7fed9c3
Source dataset
uspto-grants-2016_08
Patent number
US09416101B2

Reaction notes

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