Benzoic acid, 3-(chlorosulfonyl)- → HCID 66763110, compound

HRID 1482812Notes

Reaction equation

HRID 1482812 reaction equation
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[Cl:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[NH:20][CH2:19][CH2:18]2>>[Cl:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[N:20]([S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3])[CH2:19][CH2:18]2

Participants

3

Reactant 2

HCID 77641Benzoic acid, 3-(chlorosulfonyl)-HCID 1175965-Chloroindoline

Product 1

HCID 66763110HCID 66763110, compound

Procedure

3-(chlorosulfonyl)benzoic acid (1.0 g, 4.53 mmol) was treated with 5-chloroindoline (2.08 g, 13.60 mmol) using method A to give 3-(5-chloroindolin-1-ylsulfonyl)benzoic acid as an off white solid. Yield: 720 mg (47%). 1H-NMR: 8.09 (d, J=8.5 Hz, 2H), 7.93 (d, J=8.5 Hz, 2H), 7.48-7.43 (m, 1H), 7.27-7.23 (m, 2H), 3.97 (t, J=8.5 Hz, 2H) 2.91 (t, J=8.5 Hz, 2H).

Sources & evidence

ORD record
ord-0acf4746b1104d2194d446d601f708b3
Source dataset
uspto-grants-2016_08
Patent number
US09416101B2

Reaction notes

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