3-Chloroaniline → HCID 8497540, compound

HRID 1482818Notes

Reaction equation

HRID 1482818 reaction equation
Cl[S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[Cl:14][C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][CH:21]=1)[NH2:18]>>[Cl:14][C:15]1[CH:16]=[C:17]([NH:18][S:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=2)(=[O:4])=[O:3])[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 79323-ChloroanilineHCID 823854-(Chlorosulfonyl)benzoic acid

Product 1

HCID 8497540HCID 8497540, compound

Procedure

4-(chlorosulfonyl)benzoic acid (22) (553 mg, 2.60 mmol) was treated with 3-chloroaniline (800 mg, 6.3 mmol) using method A to give 4-(N-(3-chlorophenyl)sulfamoyl)benzoic acid as an off white solid. Yield: 382 mg (49%). 1H-NMR: 10.73 (s, 1H), 8.09 (d, J=8.5 Hz, 2H), 7.88 (d, J=8.5 Hz, 2H), 7.27 (t, J=8.5 Hz, 1H), 7.13-7.04 (m, 3H).

Sources & evidence

ORD record
ord-4b6400f44a314bfdaf80e596259d0e60
Source dataset
uspto-grants-2016_08
Patent number
US09416101B2

Reaction notes

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