HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylaniline → 4-[methyl(phenyl)sulfamoyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylaniline | HCID 7515 | — |
| Reactant | 4-(Chlorosulfonyl)benzoic acid | HCID 82385 | — |
| Product | 4-[methyl(phenyl)sulfamoyl]benzoic acid | HCID 2377201 | — |
Reaction Steps
4-(chlorosulfonyl)benzoic acid (500 mg, 2.27 mmol) was treated with N-methylaniline (729 mg, 6.8 mmol) using method A to give 4-(N-methyl-N-phenylsulfamoyl)benzoic acid as an off-white solid. Yield: 374 mg (57%). 1H-NMR: 8.09 (d, J=8.5 Hz, 2H), 7.62 (d, J=8.5 Hz, 2H), 7.38-7.28 (m, 3H), 7.13-7.08 (m, 2H), 3.17 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09416101B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-31e2cd135af2499e8e5725d56d57d709 |
| Source note | uspto-grants-2016_08 |