Potassium Hydroxide → HCID 56950743, compound

HRID 1482903Notes

Reaction equation

HRID 1482903 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([Cl:14])=[CH:9][C:8]=2[Cl:15])[N:5]=[C:4]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[C:3]=1[C:22]([O:24]CC)=[O:23].[OH-].[K+]>O>[NH2:1][C:2]1[N:6]([C:7]2[C:8]([Cl:15])=[CH:9][C:10]([Cl:14])=[CH:11][C:12]=2[Cl:13])[N:5]=[C:4]([C:16]2[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=2)[C:3]=1[C:22]([OH:24])=[O:23]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 56950741HCID 56950741, compound

Product 1

HCID 56950743HCID 56950743, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.4 mmol of Ethyl 5-amino-3-(pyridin-4-yl)-1-(2,4,6-trichlorophenyl)-1H-pyrazole-4-carb-oxylate (8) was dissolved in 20 ml and 10 ml H2O. 4 eq. (1.6 mmol) of KOH was added to the solution. The reaction was finished after 4 h reflux. The organic solvent was evaporated and the aqueous layer was neutralized in ice bath by adding conc. HCl. A colorless precipitate was filtered and recrystallized from hot ethanol.

Workup

  1. temperaturereflux
  2. customThe organic solvent was evaporated
  3. additionby adding conc. HCl
  4. filtrationA colorless precipitate was filtered
  5. customrecrystallized from hot ethanol

Sources & evidence

ORD record
ord-c7b0d1b90b0b479384cf78f4dab55852
Source dataset
uspto-grants-2016_08
Patent number
US09416123B2

Reaction notes

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