Hydrochloric Acid → HCID 90047196, compound

Participants

Reaction Conditions

Reaction Steps

(S)-tert-Butyl 2-(4-(1-(5-bromopyridin-2-yl)-1H-1,2,3-triazole-4-carboxamido)phenyl)morpholine-4-carboxylate (63 mg, 0.12 mmol) was dissolved in dioxane (0.5 ml) and a solution of HCl in dioxane (4 M, 0.36 ml, 1.44 mmol) was added. The reaction mixture was stirred for 2 hours at 60° C. After cooling, ether was added, the solid was filtered off, washed with ether and dried in vacuo at 60° C. to afford (S)-1-(5-bromopyridin-2-yl)-N-(4-(morpholin-2-yl)phenyl)-1H-1,2,3-triazole-4-carboxamide hydrochloride (48 mg, 87%) as a white solid. MS (ISP): 429.4 ({79Br} [M−H]+), 431.5 ({81Br} [M−H]+).

Provenance & Evidence