4-Bromobenzoyl chloride → HCID 90079356, compound

Participants

Reaction Conditions

Reaction Steps

1.1 tert-Butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (0.65 g; 3.06 mmol) is dissolved in 20 ml of DCM. N-Ethyldiisopropylamine for synthesis (1.56 ml; 9.19 mmol) is added and the mixture cooled to 0° C. Now 4-bromobenzoyl chloride for synthesis (0.74 g; 3.37 mmol) is dissolved in 10 ml of DCM and added dropwise to the reaction, followed by stirring at RT for 14 h. The reaction mixture is extracted with 50 ml of water. The organic layer is separated, dried over MgSO4, filtered off and then reduced to dryness under vacuo to afford 1.10 g (90.9%) 5-(4-bromo-benzoyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester 1 as a slight orange oil.

Provenance & Evidence