HCID 71271186, compound → HCID 71272053, compound

HRID 1483018Notes

Reaction equation

HRID 1483018 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([C:12]([OH:14])=[O:13])[CH:4]([C:15]2[CH:16]=[N:17]C=N[CH:20]=2)[N:3]1[CH2:21][CH:22]([CH3:24])[CH3:23].O=C1C2C(=CC(F)=CC=2)C(C(O)=O)C(C2[S:41]C(C#N)=CC=2)N1CC(C)C.O=C1C2C(=CC=C(F)C=2)C(C(O)=O)C(C2C=NN(C)C=2)N1CC(F)(F)F.O=C1C2C(=CC=CC=2)C(C(O)=O)C(C2SC(C#N)=CC=2)N1CC1CC1.O=C1C2C(=CC=CC=2)C(C(O)=O)C(C2SC(C#N)=CC=2)N1CCCC.C(N1C(C2C=NC=CC=2)C(C(O)=O)C2C(=CC(OC)=CC=2)C1=O)C(C)C>>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([C:12]([OH:14])=[O:13])[CH:4]([C:15]2[CH:16]=[N:17][S:41][CH:20]=2)[N:3]1[CH2:21][CH:22]([CH3:24])[CH3:23]

Participants

7

Reactant 6

HCID 71271186HCID 71271186, compoundHCID 71271349HCID 71271349, compoundHCID 71271971HCID 71271971, compoundHCID 71276319HCID 71276319, compoundHCID 71529663HCID 71529663, compoundHCID 71529664HCID 71529664, compound

Product 1

HCID 71272053HCID 71272053, compound

Procedure

1-oxo-2-isobutyl-3-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; 1-oxo-2-isobutyl-3-(5-cyanothiophen-2-yl)-6-fluoro-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; 1-oxo-2-(2,2,2-trifluoroethyl)-3-(1-methyl-1H-pyrazol-4-yl)-7-fluoro-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; 1-oxo-2-cyclopropylmethyl-3-(5-cyanothiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; 1-oxo-2-(1-butyl)-3-(5-cyanothiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; and 2-isobutyl-7-methoxy-1-oxo-3-(pyridin-3-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid.

Sources & evidence

ORD record
ord-c270dc9996064dd489d807b4d61b6967
Source dataset
uspto-grants-2016_08
Patent number
US09416124B2

Reaction notes

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