Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | 2(3H)-Benzoxazolone | HCID 6043 | — |
| Reactant | tert-Butyl N-(2-bromoethyl)carbamate | HCID 4103526 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 90142392 | HCID 90142392 | 65.7% |
Reaction Steps
Combine 2-(3H)-benzoxazolone (0.4 g, 2.9 mmol), tert-butyl 2-bromoethylcarbamate (715.14 mg, 3.19 mmol), potassium tert-butoxide (508.7 mg, 4.35 mmol), potassium iodide (0.1 g, 0.6 mmol) in DMF (6 mL). Heat to 80° C. and stir the mixture overnight. Filter; collect the filtrate; and purify via HPLC conditions M (See below) to provide the title compound (0.53 g, 65.6%) as an oily solid. MS (m/z): 223 (M-tBu+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09416138B2 |
|---|
| Source dataset | uspto-grants-2016_08 |
|---|
| ORD ID | ord-c68224ae532643459fb3c308ed672a5c |
|---|
| Source note | uspto-grants-2016_08 |
|---|
