HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(6-Nitro-pyridin-3-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester → Tert-butyl 4-(6-aminopyridin-3-yl)-1,4-diazepane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(6-Nitro-pyridin-3-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester | HCID 58315401 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | Tert-butyl 4-(6-aminopyridin-3-yl)-1,4-diazepane-1-carboxylate | HCID 58315396 | 122.4% |
Reaction Steps
By repeating procedures described in Example B, 4-(6-nitro-pyridin-3-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (490 mg, 1.52 mmol) is hydrogenated over Pd—C on an H-cube (Thales) (instead of under an atmosphere of hydrogen) to give 4-(6-amino-pyridin-3-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (544 mg, 98%). MS (ESI) m/z 293 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09416136B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-6c44757071bb455391684a97bbe29b98 |
| Source note | uspto-grants-2016_08 |