huagongshe.com
HRID1483071

反应详情

EQUATION

反应方程式

HRID 1483071 的结构方程式

REACTANTS

反应物

2
结构：CC(C)N1CCNCC1
HCID78013

Piperazine, 1-isopropyl-

C7H16N2

结构：CN(C)C(=O)c1cc2cnc(Nc3ccc(C=O)cn3)nc2n1C1CCCC1
HCID58315440

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)N1CCN(Cc2ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc2)CC1
HCID58315407

未命名化合物

收率 53%

PROCEDURE

实验过程

Following General Procedure B, 7-cyclopentyl-2-(5-formyl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (150 mg, 0.396 mmol) and N-isopropylpiperazine (56 mg, 0.436 mmol) gave 7-cyclopentyl-2-[5-(4-isopropyl-piperazin-1-ylmethyl)-pyridin-2-ylamino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (103 mg, 53%) [following SiO2 chromatography, eluting with 0-10% (2M NH3 in MeOH)/dichloromethane]. MS (ESI) m/z 491.3 (M+H)+ (method A).