1-Methylpiperazine → HCID 58315398, compound

Participants

Reaction Steps

Following General Procedure B, 7-cyclopentyl-2-(5-formyl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (0.2 g, 0.529 mmol) and N-methyl piperazine (58 mg, 0.582 mmol) gave 7-cyclopentyl-2-[5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide as a white off solid (0.144 g, 60%) [following further purification by SiO2 chromatography, eluting with 2-5% (2N NH3 in MeOH/dichloromethane]. MS (ESI) m/z 463.3 (M+H)− (method B).

Provenance & Evidence