6-Chloropyridine-3-carbaldehyde → HCID 58315473, compound

HRID 1483082Notes

Reaction equation

HRID 1483082 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=O)=[CH:4][CH:3]=1.Cl.[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][C:13]1=[O:18]>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:15]2[CH2:16][CH2:17][N:12]([CH3:11])[C:13](=[O:18])[CH2:14]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27640536-Chloropyridine-3-carbaldehydeHCID 170607661-Methylpiperazin-2-one--hydrogen chloride (1/1)

Product 1

HCID 58315473HCID 58315473, compoundYield 84.1%

Procedure

Following General Method B, 6-chloro-pyridine-3-carbaldehyde (500 mg, 3.532 mmol) and 1-methylpiperazine-2-one hydrochloride (559 mg, 3.709 mmol) gave 4-(6-chloro-pyridin-3-ylmethyl)-1-methyl-piperazin-2-one (712 mg, 84%) [following SiO2 chromatography, eluting with 0-10% MeOH/dichloromethane]. MS (ESI) m/z 240.1 (M+H)−

Sources & evidence

ORD record
ord-b34b3c9c1f9a40c19909ea60aec33b1e
Source dataset
uspto-grants-2016_08
Patent number
US09416136B2

Reaction notes

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